Which of the following is an example of a prostaglandin analog for glaucoma management?

• A. Latanoprost 0.005%
• B. Timolol
• C. Dorzolamide
• D. Brimonidine

Answer: (A)

Prostaglandin analgogs for glaucoma management work by increasing the outflow of aqueous humor through the uveoscleral pathway, which makes them highly effective and convenient as once-daily therapy. Latanoprost is a prostaglandin F2α analog commonly used as a first-line agent for open-angle glaucoma. It lowers intraocular pressure primarily by relaxing the ciliary muscle to enhance uveoscleral outflow. The other drugs listed are not prostaglandin analogs: timolol is a beta-blocker that reduces aqueous humor production; dorzolamide is a carbonic anhydrase inhibitor that also reduces production; brimonidine is an alpha-2 adrenergic agonist that lowers production and can modestly increase outflow. So latanoprost directly fits the category of prostaglandin analogs.