What is the mechanism of carbonic anhydrase inhibitors in glaucoma management?

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Multiple Choice

What is the mechanism of carbonic anhydrase inhibitors in glaucoma management?

Explanation:
Carbonic anhydrase inhibitors lower intraocular pressure by reducing the production of aqueous humor. They block carbonic anhydrase in the ciliary body, preventing the formation of bicarbonate. Less bicarbonate means reduced active ion transport (including sodium and bicarbonate) into the posterior chamber, and water follows. The result is decreased secretion of aqueous humor, so less fluid enters the anterior chamber and the IOP falls. They act by lowering production rather than increasing outflow, which is why this mechanism fits best.

Carbonic anhydrase inhibitors lower intraocular pressure by reducing the production of aqueous humor. They block carbonic anhydrase in the ciliary body, preventing the formation of bicarbonate. Less bicarbonate means reduced active ion transport (including sodium and bicarbonate) into the posterior chamber, and water follows. The result is decreased secretion of aqueous humor, so less fluid enters the anterior chamber and the IOP falls. They act by lowering production rather than increasing outflow, which is why this mechanism fits best.

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